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Benefits

  • 80% of patients taking Naltrexone and Bupropion lost greater than 5% of their body weight compared to 60% who were on placebo
  • Clinical trials have shown a 5% reduction in weight in patients taking Naltrexone and Bupropion
  • A 56-week clinical trial has shown that the combination of these medications coupled with lifestyle and diet changes can increase the reduction weight to 10 to 15%
  • Clinical trials have shown that Vitamin B6 has been found to improve the ratio of fat and lean muscle in your body
  • Weight loss
  • Helps to keep weight off over time
  • May help improve indicators of heart disease, high blood pressure, type 2 diabetes, and stroke
  • May improve energy, mobility, joint pain
  • Improvement in emotional and mental health, such as sleep, energy, vitality, and mood

Side-effects

  • Nausea
  • Constipation
  • Headache
  • Vomiting
  • Dizziness
  • Trouble sleeping
  • Dry mouth
  • Diarrhea
  • Seizures
  • Risk of Opioid Overdose
  • Sudden Opid Withdrawal
  • Severe Allergic Reactions
  • Increases in Blood Pressure or Heart Rate
  • Liver Damage or Hepatitis
  • Manic Episodes
  • Visual Problems (Angle-Closure Glaucoma)
  • Increased Risk of Low Blood Sugar

It should not be taken if you have a history of seizures, have high blood pressure, have a history of eating disorders, are taking certain medications like opioids, and have a history of suicidal thoughts and behaviors.

Black Box Warning: WARNING: SUICIDAL THOUGHTS AND BEHAVIORS. Bupropion has been associated with the occurrence of suicidal thoughts, actions, or unusual behavior, regardless of whether individuals are using it to treat depression. In some cases, bupropion may heighten the risk of such thoughts or actions, particularly in children, teenagers, and young adults during the initial months of treatment. If someone already has depression or other mental health conditions, taking bupropion may exacerbate these issues, especially in the early stages of treatment. It is essential to monitor and seek professional advice if any concerning changes in behavior occur.