Introduction:

Testosterone Replacement Therapy (TRT) is a personalized journey, and choosing the right administration method is crucial. At Hone, various testosterone formulations are offered, each with its own set of pros and cons. Here's a breakdown to help you make an informed decision based on your preferences:

Subcutaneous (SQ) or Intramuscular (IM) Testosterone Injections:

Pros:

• Allows for extended storage, gradual release, and prolonged presence in the blood.
• Less frequent administration with a longer half-life.
• Most potent form of testosterone.
• Relatively low cost.

Cons:

• Higher conversion to estradiol and elevation in hematocrit levels.
• Pain associated with IM injections; SQ injections are less painful.
• Injection site reactions may occur.
• Difficult to draw into an insulin syringe.

Testosterone Troche:

Pros:

• Easy administration with a rapid onset.
• Mimics physiologic diurnal release.
• Short duration of action, allowing quick discontinuation.
• Positive effect on cholesterol profile.

Cons:

• Potential irritation, inflammation, or gingivitis.
• Unpleasant bitter taste in the mouth.
• Requires two applications per day.
• Fluctuations in absorption.

Testosterone Cream:

Pros:

• Easy application with a rapid onset.
• Mimics physiologic diurnal release.
• Short duration of action for quick discontinuation.
• Positive effect on cholesterol profile.

Cons:

• Potential for contact transference.
• Fluctuations in absorption.
• Messy application.
• Potential for skin irritation.
• Requires one to two applications per day.

Conclusion:

The most effective TRT administration method depends on your personal preferences and lifestyle. All formulations at Hone are designed to help you achieve normal physiologic testosterone levels. Consider the pros and cons of each method to make an informed decision that aligns with your needs and comfort level.

This article was written by Hone Health with the help of Hone's medical director, Dr. Jim Staheli.